Spontaneous Network Activity differs by Excitation-Inhibition Ratio Using Induced Pluripotent Stem Cells Derived Cortical Neurons

カテゴリ: 研究会(論文単位)

論文No: MAG21011,MBE21003

グループ名: 【A】基礎・材料・共通部門 マグネティックス/【C】電子・情報・システム部門 医用・生体工学合同研究会

発行日: 2021/03/13

タイトル(英語): Spontaneous Network Activity differs by Excitation-Inhibition Ratio Using Induced Pluripotent Stem Cells Derived Cortical Neurons

著者名: Chen Shuyu(The University of Tokyo),Shimba Kenta(The University of Tokyo),Chang Chih-hsiang(The University of Tokyo),Kotani Kiyoshi(The University of Tokyo),Jimbo Yasuhiko(The University of Tokyo)

著者名(英語): Shuyu Chen(The University of Tokyo),Kenta Shimba(The University of Tokyo),Chih-hsiang Chang(The University of Tokyo),Kiyoshi Kotani(The University of Tokyo),Yasuhiko Jimbo(The University of Tokyo)

キーワード: E-I balance|response sparseness|in vitro|E-I balance|response sparseness|in vitro

要約(日本語): Synchronous bursting of networks of neurons, termed as ‘network bursts’, are a ubiquitous phenomenon in various neuronal networks. In this study, we cultured networks of four Excitation-Inhibition ratios. Spontaneous network activity differed as the number of inhibitory cells was increased. Although the overall firing rates remained around 5Hz/electrode after 14 days in vitro, neuron spikes were distributed more randomly when there were more inhibitory neurons. Using the electrode burst to signify network activity, we observed that network bursts were harder to form when inhibition increased. Network bursts tended to be shorter with fewer spikes involved.

要約(英語): Synchronous bursting of networks of neurons, termed as ‘network bursts’, are a ubiquitous phenomenon in various neuronal networks. In this study, we cultured networks of four Excitation-Inhibition ratios. Spontaneous network activity differed as the number of inhibitory cells was increased. Although the overall firing rates remained around 5Hz/electrode after 14 days in vitro, neuron spikes were distributed more randomly when there were more inhibitory neurons. Using the electrode burst to signify network activity, we observed that network bursts were harder to form when inhibition increased. Network bursts tended to be shorter with fewer spikes involved.

本誌: 2021年3月16日マグネティックス/医用・生体工学合同研究会－1

本誌掲載ページ: 11-14 p

原稿種別: 英語

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