単一細胞熱計測のためのpnダイオード型マイクロ熱センサ

カテゴリ: 部門大会

論文No: 28am2-B-1

グループ名: 第32回「センサ・マイクロマシンとその応用システム」シンポジウム論文集

発行日: 2015/10/21

タイトル(英語): THERMAL MICROSENSOR WITH PN JUNCTION DIODE FOR THERMAL MEASUREMENTS OF A SINGLE CELL

著者名: 山田 泰斗*，猪股 直生，小野 崇人(東北大学)

キーワード: 熱センサ,pn ダイオード,マイクロ流体チップ,褐色脂肪細胞

要約(英語): In this paper, a sensitive thermal microsensor based on a pn junction diode for heat measurements of biological single cells is developed and evaluated. By using fabricated device, heat measurement of a single brown fat cell is demonstrated. The principle of the sensor relies on the temperature dependence of the pnjunction diode resistance. This method has a capability of the highly thermal sensitivity by downsizing and an advantage of simple experimental setup using electrical circuits without any special equipment. To achieve highly sensitive heat measurement for single cells, downsizing of the sensor is necessary to reduce the heatcapacity of the sensor itself. The sensor with the pn junction diode can be downsized by microfabrication. The temperature coefficient of resistance of 1.4%/K was achieved. The temperature and thermal resolutions of the fabricated device are 1.1 mK and 73.6 nW, respectively. The heat measurements of single brown fat cellsstimulated by norepinephrine and non-stimulated were demonstrated, and different behavior in heat generation is observed.

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