３次元微細加工を応用したBody on a Chipの開発

カテゴリ: 部門大会

論文No: 30pm1-A-2

グループ名: 第32回「センサ・マイクロマシンとその応用システム」シンポジウム論文集

発行日: 2015/10/21

タイトル(英語): Development of a Body-on-a-Chip Using 3D Microstructuring Techniques

著者名: 加藤 義基，平井 義和*，亀井 謙一郎，土屋 智由，田畑 修(京都大学)

キーワード: マイクロ流体デバイス,細胞アッセイ,3次元微細加工,圧力駆動型ポンプ,プロセス最適化

要約(英語): In vitro cell-based assay with human cells is getting attention since the accuracy of preclinical predictions of drug responses should be improved to reduceing costly failures in clinical trials. In order to generate reliable predictions, we present a micro-engineered biomimetic systems “Body-on-a-Chip”, to investigate the effects ofdrugs/metabolites on various organs by assembling a closed-loop medium circulation system on one microfluidic device. For three-dimensional (3D) polymeric device fabrication, a reliable 3D lithography with the process optimization method is applied to improve the current soft-lithography technique. Our Body-on-a-Chip issuccessfully applied to evaluate the effects of an anti-cancer drug (doxorubicin) on cell survival of human heart and liver.

PDFファイルサイズ: 726 Kバイト