Brownian Dynamics Simulation for Electrophoretic Migration of DNA Nanostructures in a 2D Anisotropic Nanosieving Structure

カテゴリ: 研究会(論文単位)

論文No: BMS15031

グループ名: 【E】センサ・マイクロマシン部門 バイオ・マイクロシステム研究会

発行日: 2015/07/03

タイトル(英語): Brownian Dynamics Simulation for Electrophoretic Migration of DNA Nanostructures in a 2D Anisotropic Nanosieving Structure

著者名: Park Seongsu(京都大学),馬 志鵬(京都大学),山下 直輝(京都大学),川合 健太郎 (大阪大学),平井 義和(京都大学),土屋 智由(京都大学),田畑 修(京都大学)

著者名(英語): Seongsu Park(Kyoto University),Zhipeng Ma(Kyoto University),Yamashita Naoki(Kyoto University),Kentaro Kawai(Kyoto University),Yoshikazu Hirai(Kyoto University),Toshiyuki Tsuchiya(Kyoto University),Osamu Tabata(Kyoto University)

キーワード: Ｂｒｏｗｎｉａｎ　ｄｙｎａｍｉｃｓ|ＤＮＡ　ｏｒｉｇａｍｉ|Ｍｏｌｅｃｕｌａｒ　Ｓｉｅｖｉｎｇ|Ｍｉｃｒｏｆａｂｒｉｃａｔｉｏｎ|Ｅｌｅｃｔｒｏｐｈｏｒｅｓｉｓ|Brownian dynamics|DNA origami|Molecular Sieving|Microfabrication|Electrophoresis

要約(日本語): This study aims to establish a simulation scheme for microchip-base size-separation of DNA nanostructures, which has great potential in playing important role as a functional nanoscale building block in many applications such as MEMS. A Brownian dynamics simulation for the electrophoretic migration of DNA nanostructure with a cylinder-base rigid-body in a micro-fabricated sieving structure was proposed. We checked the validity by comparing the simulated results with reported result for short dsDNA fragments. This simulation method will be exploited to understand parameter dependency of size-separation of DNA origami in ANA in the future.

要約(英語): This study aims to establish a simulation scheme for microchip-base size-separation of DNA nanostructures, which has great potential in playing important role as a functional nanoscale building block in many applications such as MEMS. A Brownian dynamics simulation for the electrophoretic migration of DNA nanostructure with a cylinder-base rigid-body in a micro-fabricated sieving structure was proposed. We checked the validity by comparing the simulated results with reported result for short dsDNA fragments. This simulation method will be exploited to understand parameter dependency of size-separation of DNA origami in ANA in the future.

原稿種別: 英語

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