Microcontact Printing for Cell Patterning and Optoporation: Toward Massively Parallel Intranuclear Delivery

カテゴリ: 研究会(論文単位)

論文No: BMS18013

グループ名: 【E】センサ・マイクロマシン部門 バイオ・マイクロシステム研究会

発行日: 2018/03/05

タイトル(英語): Microcontact Printing for Cell Patterning and Optoporation: Toward Massively Parallel Intranuclear Delivery

著者名: グプタ ハルシュ(豊橋技術科学大学),舟橋 圭佑(豊橋技術科学大学),澤井 慎(豊橋技術科学大学),岩崎 真己(豊橋技術科学大学),峰村 俊輝(豊橋技術科学大学),シャインデ パッラビ(インド工科大学、マドラス、インド),サブハラ サントラ ツィン(インド工科大学、マドラス、インド),柴田 隆行(豊橋技術科学大学),永井 萌土(豊橋技術科学大学)

著者名(英語): Harsh Gupta(Toyohashi University of Technology),Keisuke Funahashi(Toyohashi University of Technology),Shin Sawai(Toyohashi University of Technology),Naoki Iwasaki(Toyohashi University of Technology),Toshiki Minemura(Toyohashi University of Technology),Pallavi ShindeTuhin(Indian Institute of Technology Madras India),Subhra Santra(Indian Institute of Technology Madras India),TAKAYUKI SHIBATA(Toyohashi University of Technology),MOETO NAGAI(Toyohashi University of Technology)

キーワード: 細胞内送達|マイクロコンタクトプリント|オプトポレーション|ナノ秒パルス放射|Intracellular delivery|Micro-contact printing|optoporation|nano-second pulsed radiation

要約(日本語): With the increasing need of regenerative medicines, cell therapy, and biopharmaceutical drug, it isnecessary to develop a method for massively parallel delivery and uniform transfection. Thisresearch explores the possibility of using ?CP (using cell adhesive and cell blocking agents) forprinting massive number of cells on a substrate and using optoporation methods (nano-secondpulsed radiation) to perforate cell membranes. With combining these two methods, a stand-alonemicro-device capable of performing localized intracellular delivery will be developed.

要約(英語): With the increasing need of regenerative medicines, cell therapy, and biopharmaceutical drug, it isnecessary to develop a method for massively parallel delivery and uniform transfection. Thisresearch explores the possibility of using ?CP (using cell adhesive and cell blocking agents) forprinting massive number of cells on a substrate and using optoporation methods (nano-secondpulsed radiation) to perforate cell membranes. With combining these two methods, a stand-alonemicro-device capable of performing localized intracellular delivery will be developed.

原稿種別: 英語

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