【Invited】Visible light-responsive novel metallo-antibiotics with potential antibiofilm, antibacterial and wound healing activity

カテゴリ: 部門大会

論文No: 2-C-p1-2

グループ名: 【A】令和６年電気学会基礎・材料・共通部門大会

発行日: 2024/08/26

タイトル(英語): 【Invited】Visible light-responsive novel metallo-antibiotics with potential antibiofilm, antibacterial and wound healing activity

著者名: Mukherjee Sudip(IIT (BHU)), UPADHYAY Anjali(IIT (BHU)), Banerjee Samya(Chemistry, IIT (BHU)), Mandal Arif Ali(Chemistry, IIT (BHU))

キーワード: Metallo-antibiotics|Photodynamic Therapy|Antibacterial|Antibiofilm|Wound Healing|Photosensitizer

要約(日本語): Growing challenges with antibiotic resistance pose immense challenges in combating microbial infections and biofilm prevention on medical devices. Herein, we synthesized and characterized different Ru(II)- and Fe(II) complexes useful for aPDT performances. Upon light exposure these metallo-complexes demonstrated enhanced antimicrobial activity on visible-light. Mechanistic studies revealed that inhibition of bacterial growth was due to the generation of oxidative stress (via NADH oxidation and ROS generation). Moreover, the lead complexes demonstrated improved antibiofilm property when coated on a polydimethylsiloxane (PDMS) disk. Lead complex was utilized for rapid healing of infected wounds in rat model.

要約(英語): Growing challenges with antibiotic resistance pose immense challenges in combating microbial infections and biofilm prevention on medical devices. Herein, we synthesized and characterized different Ru(II)- and Fe(II) complexes useful for aPDT performances. Upon light exposure these metallo-complexes demonstrated enhanced antimicrobial activity on visible-light. Mechanistic studies revealed that inhibition of bacterial growth was due to the generation of oxidative stress (via NADH oxidation and ROS generation). Moreover, the lead complexes demonstrated improved antibiofilm property when coated on a polydimethylsiloxane (PDMS) disk. Lead complex was utilized for rapid healing of infected wounds in rat model.

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