A study on the relationship between ultrasound irradiation and membrane permeability in cell membrane drilling
A study on the relationship between ultrasound irradiation and membrane permeability in cell membrane drilling
カテゴリ: 部門大会
論文No: SS2-1
グループ名: 【C】2021年電気学会電子・情報・システム部門大会
発行日: 2021/09/08
タイトル(英語): A study on the relationship between ultrasound irradiation and membrane permeability in cell membrane drilling
著者名: 梶江 佳乃(東京工業大学),Povarasoontorn Panida(東京工業大学),Peng Zugui(東京工業大学),柴田 孝(富山大学),榛葉 健太(東京大学),宮本 義孝(国立成育医療研究センター),八木 透(東京工業大学)
著者名(英語): Kano Kajie (Tokyo Institute of Technology),Takashi Shibata (University of Toyama),Kenta Shimba (University of Tokyo),Yoshitaka Miyamoto (National Center for Child Health and Development),Tohru Yagi (Tokyo Institute of Technology)
キーワード: DDS|Liposome|Ultrasound|Cell membrane|Membrane permeability
要約(日本語): In the ultrasound-based drug delivery system (DDS), the target cells are irradiated with ultrasonic waves to temporarily drill the cell membrane. At the same time, the drug is released from the liposomes and taken up by the cells. However, the optimal irradiation conditions for the ultrasound to maximize drug uptake are often still unclear. In this experiment, we irradiate artificial cell membranes with ultrasonic waves in a solution containing a fluorescent substance that is considered to be a drug. As a result, we have found the irradiation condition that increases the uptake the most. In the future, we will continue to conduct experiments using various irradiation conditions to search for the optimal conditions that maximize the effect of ultrasound irradiation and to apply it to DDS.
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