Network-shape muscle cell sheets using magnetic nanoparticles

カテゴリ: 部門大会

論文No: SS2-8

グループ名: 【C】2021年電気学会電子・情報・システム部門大会

発行日: 2021/09/08

タイトル(英語): Network-shape muscle cell sheets using magnetic nanoparticles

著者名: 桐原 佑司（東京工業大学）,榛葉 健太（東京大学）,宮本 義孝（国立成育医療研究センター）,八木 透（東京工業大学）

著者名(英語): Yuji Kirihara (Tokyo Institute of Technology),Kenta Shimba (The University of Tokyo),Yoshitaka Miyamoto (National Center for Child Health and Development),Tohru Yagi (Tokyo Institute of Technology)

キーワード: Myoblast|C2C12 cell|Magnetite|Magnetic force|Tissue engineering

要約(日本語): Engineering skeletal muscle tissue has gained attention greatly. However, the conventional tissues have two major problems; 1) the low density of cells, and 2) the lack of alignment of the muscle fibers. Therefore, we propose a method to increase the density and align the fiber using magnetic nanoparticles and a network-shaped tissue. In this study, embedding magnetic nanoparticles on mouse C2C12 myoblast cells, we evaluate the cellular uptake of the particles and the effects on cells. The current results show that the muscle fiber thickness tends to slightly decrease in C2C12 with internalized magnetite. Therefore, we build a network-like structure with a range of density that does not affect the cell to measure the contraction force.

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