Analysis of the role of neural stem cells and their development on the electrical activity of a hippocampal culture

カテゴリ: 部門大会

論文No: SS2-9

グループ名: 【C】2021年電気学会電子・情報・システム部門大会

発行日: 2021/09/08

タイトル(英語): Analysis of the role of neural stem cells and their development on the electrical activity of a hippocampal culture

著者名: 森谷 文香（東京大学）,榛葉 健太（東京大学）,小谷 潔（東京大学）,神保 泰彦（東京大学）

著者名(英語): Fumika Moriya (The University of Tokyo),Kenta Shimba (The University of Tokyo),Kiyoshi Kotani (The University of Tokyo),Yasuhiko Jimbo (The University of Tokyo)

キーワード: Neural stem cells|Spontaneous activity|High-density microelectrode array|Hippocampus

要約(日本語): In the hippocampus, newborn neurons can be produced even after prenatal development. However, the correlation between neurogenesis and learning and memory function is still unclear. Here, we investigated the relationship between neurogenesis and the dynamics of hippocampal neuronal networks. We administered DAPT to a hippocampal culture with different time courses to control the proliferation and differentiation of neural stem cells. By comparing the spontaneous activity among 3 conditions using a high-density microelectrode array, we assessed the effect of neural stem cells and their development on the dynamics of the hippocampal network over culturing time. Our results give new insight into the role of neural stem cells in hippocampal electrical activity.

PDFファイルサイズ: 509 Kバイト