Formation of Network Activity Modification toward in vitro Spatial-temporal Memory via Hippocampus-cortex Co-culture

カテゴリ: 部門大会

論文No: TC2-7

グループ名: 【C】2021年電気学会電子・情報・システム部門大会

発行日: 2021/09/08

タイトル(英語): Formation of Network Activity Modification toward in vitro Spatial-temporal Memory via Hippocampus-cortex Co-culture

著者名: 張 智翔（東京大学）,榛葉 健太（東京大学）,朝比奈 昂洋（東京大学）,古川 拓磨（東京大学）,小谷 潔（東京大学）,神保 泰彦（東京大学）

著者名(英語): Chihhsiang Chang (The University of Tokyo),Kenta Shimba (The University of Tokyo),Takahiro Asahina (The University of Tokyo),Takuma Furukawa (The University of Tokyo),Kiyoshi Kotani (The University of Tokyo),Yasuhiko Jimbo (The University of Tokyo)

キーワード: Spatial-temporal Memory|Hippocampus|Cortex|Microelectrode array|Micro-tunnel

要約(日本語): In vitro cultures have long been used to investigate basic properties of neuronal networks. In this study, we ask the question if neuronal networks without functional circuits are capable of long-term memories. To answer the question, a hippocampal-cortical co-culture model was used. Our co-culture model was developed by connecting dissociated hippocampal-cortical networks through micro-tunnel device. Memory was designed as spatial-temporal events as series of electrical stimuli given first in one neuronal network, followed by series of stimuli in another network with a delay of time. Our results showed modification in evoked response by electrical stimulation, and lasted in trails after several minutes, suggesting possibility of spatial-temporal memory ability in basic neuronal networks.

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