Magnetic Stimulation Conditions Needed for Localized Electrophysiological Responses in Mouse Auditory Cortex in vivo

カテゴリ: 部門大会

論文No: PS1-17

グループ名: 【C】2022年電気学会電子・情報・システム部門大会

発行日: 2022/08/24

タイトル：Magnetic Stimulation Conditions Needed for Localized Electrophysiological Responses in Mouse Auditory Cortex in vivo

タイトル(英語): Magnetic Stimulation Conditions Needed for Localized Electrophysiological Responses in Mouse Auditory Cortex in vivo

著者名: 吉川 隆洋（北海道大学）,舘野 高（北海道大学）

著者名(英語): Takahiro Yoshikawa (Hokkaido University),Takashi Tateno (Hokkaido University)

キーワード: 聴覚皮質|脳刺激|電場|有限要素法|小型コイル経頭蓋磁気刺激|Auditory Cortex|Brain Stimulation|Electric Field|Finite Element Method|Millimeter-Sized CoilTranscranial Magnetic Stimulation

要約(日本語): Magnetic stimulation (MS) eases brain disorders through electric field induced by coils. Although therapeutic effects are known to be modulated by stimulation patterns, required conditions are partially examined. To reveal the conditions, experimental validations in small animals are needed. However, related studies used larger coils designed for humans, which cannot stimulate specific brain regions. To investigate the conditions of localized MS, we stimulated mouse auditory cortex (ACx) in vivo using a millimeter-sized coil. Under MS conditions estimated by the simulation of electric field in the brain, electrophysiological responses were significantly different compared to sham conditions. Here, we discuss the practical conditions of MS to locally induce neural activity in mouse ACx.