A piezoelectric micromachined ultrasound transducer with the interface of simultaneous measurement of neural activity in vitro

カテゴリ: 部門大会

論文No: SS2-1

グループ名: 【C】2022年電気学会電子・情報・システム部門大会

発行日: 2022/08/24

タイトル(英語): A piezoelectric micromachined ultrasound transducer with the interface of simultaneous measurement of neural activity in vitro

著者名: 古川 凌（北海道大学）,舘野 高（北海道大学）

著者名(英語): Ryo Furukawa (Hokkaido University),Takashi Tateno (Hokkaido University)

キーワード: 脳スライス|カルシウムイメージング|微細加工|マイクロトランスデューサ|圧電材料超音波刺激|Brain slice|Calcium imaging|Microfabrication|Microfabricated transducer|Piezoelectric materialUltrasound stimulation

要約(日本語): Ultrasound (US) stimulation is expected to noninvasively stimulate the local and deep areas of the brain. However, the cellular mechanisms of neural activation are unclear. Moreover, conventional open-loop stimulators have a risk of over-inducing neural activity for long-time uses, resulting in unnecessary responses. Here, we have developed a piezoelectric micromachined US transducer (PMUT) to modulate the neural activities of brain slices at a cellular level. Considering the future applications of closed-loop US stimulation, we incorporated recording microelectrodes onto the PMUT. To examine the possibility of our fabricated device, we measured the PMUT-driven cellular responses. We discuss the probability of a closed-loop US stimulation system with high resolution in future applications.