A study on liposome-encapsulated hydrogel patches for ultrasound triggered transdermal DDS

カテゴリ: 部門大会

論文No: SS2-3

グループ名: 【C】2022年電気学会電子・情報・システム部門大会

発行日: 2022/08/24

タイトル(英語): A study on liposome-encapsulated hydrogel patches for ultrasound triggered transdermal DDS

著者名: 梶江 佳乃（東京工業大学）,彭 祖癸（東京工業大学）,榛葉 健太（東京大学）,宮本 義孝（国立成育医療研究センター）,柴田 孝（富山大学）,八木 透（東京工業大学）

著者名(英語): Kano Kajie (Tokyo Institute of Technology),Zugui Peng (Tokyo Institute of Technology),Kenta Shimba (University of Tokyo),Yoshitaka Miyamoto (National Center for Child Health and Development),Takashi Shibata (University of Toyama),Tohru Yagi (Tokyo Institute of Technology)

キーワード: Transdermal drug delivery systems (TDDSs)|Ultrasound|Liposome|Hydrogel|Controlled release

要約(日本語): Transdermal drug delivery systems (TDDSs) have many advantages over conventional drug delivery routes such as oral and hypodermic injections. TDDS reduces the patient burden and avoids the first-pass metabolism effects. However, further applications of TDDS are limited by the high barrier function of the skin and uncontrolled drug release. In this study, we will prepare nanosized liposomes which load fluorescent substances as drug models, encapsulate them into a hydrogel patch, and irradiate ultrasound to the patch for drug release. By comparing fluorescent intensity outside the patch before and after irradiation, we attempt to show that this system improves receptivity passing through the skin barrier and controls drug release by using ultrasound as a trigger.