Construction and evaluation of millimeter-sized coils for modulating mice auditory cortex by magnetic stimulation

カテゴリ: 部門大会

論文No: SS1-2

グループ名: 【C】2023年電気学会電子・情報・システム部門大会

発行日: 2023/08/23

タイトル(英語): Construction and evaluation of millimeter-sized coils for modulating mice auditory cortex by magnetic stimulation

著者名: 吉川 隆洋（北海道大学）,舘野 高（北海道大学）

著者名(英語): Takahiro Yoshikawa (Hokkaido University),Takashi Tateno (Hokkaido University)

キーワード: transcranial magnetic stimulation|rodent-specific coil|theta burst stimulation|plasticity|auditory cortexfinite element modelling

要約(日本語): Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method for treating tinnitus. However, its effectiveness is limited due to the fragility and variability of rTMS, and the inhibitory mechanisms underlying tinnitus treatments remain unknown. In this study, a millimeter-sized coil was constructed to stimulate the auditory cortex in mice with low-intensity intermittent theta-burst stimulation (iTBS). We have found that iTBS increased amplitudes of both immediate and late peaks of local field potentials in the auditory cortex, which suggests that the modulation mechanism involves both cellular and network plasticity. Further investigations are needed to understand the effects of iTBS on auditory-specific features and to clinically apply it to hearing disorder treatments.