Distinct Characteristics of Mismatch Negativity Responses Induced by Different Anesthetic Agents via Multi-site Electroencephalographic Recordings in the Mouse Brain

カテゴリ: 部門大会

論文No: SS1-1

グループ名: 【C】2024年電気学会電子・情報・システム部門大会

発行日: 2024/08/28

タイトル(英語): Distinct Characteristics of Mismatch Negativity Responses Induced by Different Anesthetic Agents via Multi-site Electroencephalographic Recordings in the Mouse Brain

著者名: 川勝 孝基（北海道大学　大学院情報科学院）,舘野 高（北海道大学　大学院情報科学研究院）

著者名(英語): Koki Kawakatsu (Hokkaido University),Takashi Tateno (Hokkaido University)

キーワード: electroencephalogram|mismatch negativity|multi-site recordings|anesthetic|chronic experimentationminimally invasive

要約(日本語): A biomarker for detecting symptoms of brain disorders is crucial for preventive medicine. The mismatch negativity (MMN) is an event-related potential component observed in electroencephalography (EEG) and serves as such a biomarker. However, little is known about the mechanisms underlying MMN generation with different anesthetic agents. To address this gap, we developed a flexible substrate enabling easy recording of electrical activity via multi-site screw electrodes implanted in the mouse head. Our experimental results demonstrate that different types of anesthesia induced distinct MMN properties in EEG responses, suggesting that anesthetic action involves varying mechanisms within the brain. Our method utilizing this biomarker holds promise for the diagnosis of specific brain disorders.