効率的にシナプス可塑性を誘導する脳刺激法の開発と機序解明に向けて

カテゴリ: 部門大会

論文No: TC4-2-1

グループ名: 【C】2024年電気学会電子・情報・システム部門大会

発行日: 2024/08/28

タイトル(英語): Developing brain stimulation methods for efficiently inducing synaptic plasticity and elucidating its mechanisms

著者名: 古川 凌（北海道大学）,舘野 高（北海道大学）

著者名(英語): Ryo Furukawa (Hokkaido University),Takashi Tateno (Hokkaido University)

キーワード: 脳スライス|微細加工|マイクロトランスデューサ|シナプス可塑性|超音波刺激|Brain slice|Microfabrication|Micro transducer|Synaptic plasticity|Ultrasound stimulation

要約(日本語): Inducing synaptic plasticity shows promise for treating brain diseases, yet effective protocols and detailed mechanisms within specific brain regions using neuromodulation methods are not well-understood. Traditional noninvasive neuromodulation techniques that use electromagnetic approaches are limited by spatial resolution and depth penetration. In contrast, ultrasound (US) stimulation presents a promising alternative. However, the precise cellular mechanisms behind neural activation through US remain unclear, particularly due to a lack of adequate cellular experimental systems. In this context, we report recent findings on synaptic plasticity dynamics in cortical slices. Additionally, we present our latest studies in micromachines within a US stimulation system both in vitro and in vivo.