Evaluation of Structural Characteristics of Burst Initiation Circuits in Area Restricted Neuronal Networks

カテゴリ：部門大会

論文No：SS1-1

グループ名：【C】2025年電気学会電子・情報・システム部門大会

発行日：2025/8/20

タイトル(英語)：Evaluation of Structural Characteristics of Burst Initiation Circuits in Area Restricted Neuronal Networks

著者名：山岸 優朔（東京大学）,榛葉 健太（東京大学）,小谷 潔（東京大学）

著者名(英語)： Yusaku Yamagishi (The University of Tokyo),Kenta Shimba (The University of Tokyo),Kiyoshi Kotani (The University of Tokyo)

キーワード：神経細胞,神経ネットワーク,分散培養系,同期バースト,微小電極アレイ局所回路,neuron,neuronal network,dissociated culture,synchronized burst,micro-electrode arraylocal circuit

要約(日本語)：Synchronized bursts, where multiple neurons fire simultaneously at high frequency, are thought to originate within local circuits of the neuronal network; however, the structural characteristics of these circuits remain unclear. In this study, we aimed to elucidate the structural features of such local circuits by constructing micro-networks that allow comprehensive measurement of the entire network. We developed micro-networks on high-density microelectrode arrays, ensuring that all neurons were located within the electrode area. Burst initiation points were localized using the recorded signals. We found that the initiation points had hub structures in the connectivity map. This result suggests that hub structures may play a role in efficient information transfer within neuronal networks.

本誌掲載ページ：1765-1767p

原稿種別：英語

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