hiPSC-derived kidney organoids source proximal tubule cells capable of modeling ADPKD on a microphysiological system

カテゴリ: 部門大会

論文No: 6P5-PS-60

グループ名: 【E】第40回「センサ・マイクロマシンと応用システム」シンポジウム

発行日: 2023/10/31

タイトル(英語): hiPSC-derived kidney organoids source proximal tubule cells capable of modeling ADPKD on a microphysiological system

著者名: MA CHENG(京都大学), Banan Sadeghian Ramin(), 藤本 和也(京都大学), 荒岡 利和(京都大学), 横川 隆司(京都大学)

キーワード: hiPSC|ADPKD|micro physiological systems|proximal tubule|flow-induced Ca2+ signaling|hiPSC|ADPKD|micro physiological systems|proximal tubule|flow-induced Ca2+ signaling

要約(日本語): we report realization of a kidney proximal tubule-on-a-chip by seeding hiPSC-derived cells for the first time showing higher expression levels of proximal tubule proteins over those of immortalized cells (RPTECs). Alongs

要約(英語): we report realization of a kidney proximal tubule-on-a-chip by seeding hiPSC-derived cells for the first time showing higher expression levels of proximal tubule proteins over those of immortalized cells (RPTECs). Alongside, we demonstrated the dynamics of flow-induced Ca2+ signaling under different flow-induced shear stress values. This can be helpful in on-chip modeling of autosomal dominant polycystic kidney disease (ADPKD) by comparing with patient-derived iPS cells.

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