伸展細胞のin situ観察を可能にする細胞伸展マイクロデバイスの開発

カテゴリ: 部門大会

論文No: MC7-6

グループ名: 【C】平成21年電気学会電子・情報・システム部門大会講演論文集

発行日: 2009/09/03

タイトル(英語): Development of cell stretching microdevice for in situ observation of stretched cell

著者名: 佐藤 克也(徳島大学),鎌田慧 (山口大学),南 和幸(山口大学)

著者名(英語): Katsuya Sato(The University of Tokushima),Satoshi Kamada(Yamaguchi University),Kazuyuki Minami(Yamaguchi University)

キーワード: 再生医療|生体医工学|MEMS|細胞力覚|骨芽細胞|Tissue Engineering|Biomedical Engineering|Micro Electro Mechanical System|Cell Mechanosensitivity|Osteoblast

要約(日本語): In this study, we have developed a novel cell stretching micro device to observe in situ cellular response to mechanical stimuli. In conventional cell stretching device, rigid displacement of cell body during stretching operation is not negligible. And this rigid displacement makes it difficult to observe essential initial cellular response. The novel micro device is fabricated by applying MEMS technique, and consists of a transparent elastic micro chamber and a micro linkage mechanism. We demonstrated availability of fabrication process, and evaluated performance of the micro device. When applying a stretch to chamber, rigid displacement was well suppressed. This result indicated a potential of this device to observe instant initial cellular response to stretching mechanical stimuli.

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