Detecting Light Response Patterns of rd1 Mouse Retinae: Electrophysiological and Optical Challenges

カテゴリ: 部門大会

論文No: PS1-7

グループ名: 【C】平成24年電気学会電子・情報・システム部門大会講演論文集

発行日: 2012/09/05

タイトル(英語): Detecting Light Response Patterns of rd1 Mouse Retinae: Electrophysiological and Optical Challenges

著者名: Kosmas Deligkaris(RIKEN,Osaka University),Kaneko Jun(RIKEN),Fiscella Michele(ETH Zurich),L. Jones Ian (ETH Zurich),Engelene Obien Marie (RIKEN),Hierlemann Andreas(ETH Zurich),Takahashi Masayo(RIKEN),Frey Urs(RIKEN,Osaka University)

著者名(英語): Kosmas Deligkaris(RIKEN,Osaka University),Kaneko Jun(RIKEN),Fiscella Michele(ETH Zurich),L. Jones Ian (ETH Zurich),Engelene Obien Marie (RIKEN),Hierlemann Andreas(ETH Zurich),Takahashi Masayo(RIKEN),Frey Urs(RIKEN,Osaka University)

キーワード: Extracellular electrophysiology|CMOS microelectrode arrays|Optical stimulation|Retina

要約(日本語): Retinitis Pigmentosa (RP), a retina disease, alters the electrophysiological properties of retinal cells and circuitry, leading to "pathological" visual input encoding with abnormally high levels of spontaneous spiking activity. Recordings of preserved light responses of RP mouse-model (e.g. rd1) retinae can reveal the altered encoding. However, high spatiotemporal resolution is needed for activity recording and optical stimulation. For stimulation, the optical pathway to the retina should be clear of artifacts (e.g. dust, bubbles in medium). For recording, MEA including active circuitry can provide high spatiotemporal resolution. Here, we present a work in progress that addresses these issues. Sample light responses, in the absence of spontaneous activity, of rd1 mouse retinae are shown.

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