Stability of neuronal electrical activity pattern evoked by input stimulation depends on culture days.

カテゴリ: 部門大会

論文No: ES1-1

グループ名: 【C】平成26年電気学会電子・情報・システム部門大会講演論文集

発行日: 2014/09/03

タイトル(英語): Stability of neuronal electrical activity pattern evoked by input stimulation depends on culture days.

著者名: Yoshinori Matsui(Kwansei Gakuin University),Keisuke Izutani(Kwansei Gakuin University),Hidekatsu Itoh(Kwansei Gakuin University),Wataru Minoshima(Kwansei Gakuin University),Suguru N. Kudoh (Kwansei Gakuin University)

著者名(英語): Yoshinori Matsui(Kwansei Gakuin University),Keisuke Izutani(Kwansei Gakuin University),Hidekatsu Itoh(Kwansei Gakuin University),Wataru Minoshima(Kwansei Gakuin University),Suguru N. Kudoh (Kwansei Gakuin University)

キーワード: stability|network dynamics|dissociated culture|spontaneous activity|evoked activity

要約(日本語): The rat hippocampal dissociated culture on multi electrodes array dish (MED) is useful as the smallest brain model to elucidate the principle of brain information processing. Rat hippocampal neuronal cells were cultured on the dish with 64 planer micro electrodes. We analyzed stability of neuronal electrical activity pattern evoked by input stimulation. Variance of the number of electrical spike activity in the certain time window decreased after the stimulation and then gradually recovered. On the contrary, the electrical stimulation increased the variance of spike number on 60~70 DIV neuronal network. These results suggest that the effect of electrical stimulation on the stability of neuronal activity depends on the development of cultured neuronal network.

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