State of Parkinson's disease is related to the activity of the dorsolateral striatum

カテゴリ: 部門大会

論文No: TC4-8

グループ名: 【C】平成26年電気学会電子・情報・システム部門大会講演論文集

発行日: 2014/09/03

タイトル(英語): State of Parkinson's disease is related to the activity of the dorsolateral striatum

著者名: 菊田 里美(東北大学),中村 幸代(徳島大学),山村 行生(徳島大学),柳川 右千夫(群馬大学),田村 篤史(東北大学),本間経康 (東北大学),田村 元(東北大学),笠原 二郎(徳島大学),小山内 実(東北大学)

著者名(英語): Satomi Kikuta(Tohoku University),Yukiyo Nakamura(The University of Tokushima),Yukio Yamamura(The University of Tokushima),Yuchio Yanagawa(Gunma University),Atsushi Tamura(Tohoku University),Noriyasu Homma(Tohoku University),Hajime Tamura(Tohoku University),Jiro Kasahara(The University of Tokushima),Makoto Osanai(Tohoku University)

キーワード: マンガン造影MRI|基底核|カルシウムイメージングカルシウムイメージング|manganese enhanced MRI|basal ganglia|calcium imaging

要約(日本語): Parkinson's disease (PD) is characterized by degeneration of dopaminergic neurons in substantia nigra pars compacta, leading to the depletion of dopamine in the striatum, and it is thought to cause changes of neuronal activities in basal ganglia. However, the relation of the changes of the neuronal activities of each region of basal ganglia and the pathological state of PD is ambiguous. Here we show that the activity of the dorsolateral striatum is correlated to the pathological state of PD. We found in the mice model of PD (PD-mice) that the activity of dorsolateral striatum analyzed by activation-induced manganese-enhanced MRI (AIME-MRI) is significantly correlated to tyrosine hydroxylase-immunoreactivity in striatum, which is known to correlate to the motor performance in PD mice.

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