A Simulation Model of Insulin Granule Dynamics in Pancreatic Beta Cell Using Tensor Field

カテゴリ: 部門大会

論文No: SS6-6

グループ名: 【C】平成27年電気学会電子・情報・システム部門大会講演論文集

発行日: 2015/08/27

タイトル(英語): A Simulation Model of Insulin Granule Dynamics in Pancreatic Beta Cell Using Tensor Field

著者名: Yuko Nakakuki(Kobe University),Takuya Matsumoto(Kobe University),Hisashi Tamaki(Kobe University),Tadao Shibasaki(Kobe University),Harumi Takahashi(Kobe University),Yasuhiro Sunaga(RIKEN),Hideo Yokota(RIKEN)

著者名(英語): Yuko Nakakuki(Kobe University),Takuya Matsumoto(Kobe University),Hisashi Tamaki(Kobe University),Tadao Shibasaki(Kobe University),Harumi Takahashi(Kobe University),Yasuhiro Sunaga(RIKEN),Hideo Yokota(RIKEN)

要約(日本語): Recently, type 2 diabetes (T2DM) is rapidly increasing worldwide. It is known that T2DM in East Asians including Japanese is characterized by dysfunction of beta cell and impairment in insulin secretion from pancreatic beta cells. Thus, the elucidation of the mechanisms of insulin secretion is important for the understanding of the pathophysiology of the disease and for the treatment and the development of drugs for T2DM. In this research, we constructed a simulation model of insulin granule dynamics in pancreatic beta cell that is newly proposed by using tensor field based on empirical and also biological knowledge. Moreover, through computational experiments, the validity of the proposed model is shown.

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