A Simulation Model of Insulin Granule Dynamics in Pancreatic Beta Cell with Module Structure

カテゴリ: 部門大会

論文No: SS3-9

グループ名: 【C】平成28年電気学会電子・情報・システム部門大会講演論文集

発行日: 2016/08/31

タイトル(英語): A Simulation Model of Insulin Granule Dynamics in Pancreatic Beta Cell with Module Structure

著者名: 高山 周平(神戸大学),中久木 優子(神戸大学),松本 卓也(神戸大学),玉置 久(神戸大学),高橋 晴美(神戸大学),須永 泰弘(理研),横田 秀夫(理研)

著者名(英語): Shuhei Takayama|Yuko Nakakuki|Takuya Matsumoto|Hisashi Tamaki|Harumi Takahashi|Yasuhiro Sunaga|Hideo Yokota

キーワード: シミュレーション|膵臓β細胞|インスリン顆粒動態インスリン顆粒動態|Simulation|Pancreatic Beta Cell|Insulin Granule Dynamics

要約(日本語): Recently, the number of diabetic patients is increasing. While it is considered that impairment of insulin secretion causes such type-2 diabetes, the mechanism of insulin secretion in pancreatic beta cells is still unclear. In our research, in order to have a deeper knowledge on the mechanism, simulation-based approach has been adopted. An improved simulation model of insulin granule dynamics is proposed based on bio-imaging data and medical background. Here, a keynote point is to represent the outer layer by introducing a module structure. Through some simulation experiments by using the proposed model, it is confirmed that the results are consistent with the medical knowledge currently obtained. This shows the validity and the potential of the proposed model.

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