Vagus Nerve Stimulation Increases Multi-unit Activity in Superficial Layers of Rat Auditory Cortex

カテゴリ: 部門大会

論文No: TC6-1

グループ名: 【C】平成29年電気学会電子・情報・システム部門大会講演論文集

発行日: 2017/09/06

タイトル(英語): Vagus Nerve Stimulation Increases Multi-unit Activity in Superficial Layers of Rat Auditory Cortex

著者名: Kaunitz Lisandro(東京大学),白松（磯口） 知世(東京大学),日露 理英(東京大学),井林 賢志(東京大学),川合 謙介(自治医科大学),高橋 宏知(東京大学)

著者名(英語): Lisandro Kaunitz|Tomoyo I.Shiramatsu|Rie Hitsuyu|Kenji Ibayashi|Kensuke Kawai|Hirokazu Takahashi

キーワード: 迷走神経刺激|聴皮質|マルチユニット活動マルチユニット活動|Vagus nerve stimulation|auditory cortex|Multiunit activity

要約(日本語): Vagus nerve stimulation (VNS), the electrical stimulation of the vagus nerve at regular intervals, is often used to alleviate epileptic symptoms. Although VNS constitutes an efficient treatment for patients suffering from refractory epilepsy (Vonck and Boon 2008), the mechanisms and physiological effects that VNS exerts on the neural activity across layers of cortex remains elusive. We used the rat model and multi electrode arrays to investigate the effects of VNS on multiunit activity (MUA) across layers of auditory cortex. VNS increased MUA in the most superficial layers of the auditory cortex but had no effect in deeper layers of cortex. Our results have implications for understanding the mechanisms of VNS and for improving the stimulation strategies and clinical outcome of patients.

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