Changes in Activity of Cultured Hippocampal Networks in a Closed-loop Neuro-robotic Environment

カテゴリ: 部門大会

論文No: TC6-22

グループ名: 【C】平成29年電気学会電子・情報・システム部門大会講演論文集

発行日: 2017/09/06

タイトル(英語): Changes in Activity of Cultured Hippocampal Networks in a Closed-loop Neuro-robotic Environment

著者名: 伊東 大輔(Istituto Italiano di Tecnologia),Tessadori Jacopo(Istituto Italiano di Tecnologia),Buccelli Stefano(Istituto Italiano di Tecnologia),Chiappalone Michela(Istituto Italiano di Tecnologia)

著者名(英語): Daisuke Ito|Jacopo Tessadori|Stefano Buccelli|Michela Chiappalone

キーワード: 培養神経回路網|微小電極アレイ|cultured neuronal network|microelectrode array

要約(日本語): Bi-directional interaction between the neuronal system and the environment is essential for living organisms. To better study this interaction, a hybrid neuro-robotic architecture was developed, where a biological neuronal network was able to communicate with a small wheeled robot. We investigated the impact of tetanic stimulation on network activity of hippocampal culture grown on grids of 60 substrate-embedded microelectrode arrays. We found that closed-loop tetanic stimulation produced an enhancement of activity in terms of evoked response, not seen in control and sham (i.e. open-loop tetanic stimulation) experiments. The obtained results demonstrate that activity-dependent interaction with the environment is essential to significantly impact network behavior.

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