Development of a Sensory Neuron Axon Guidance Method Utilizing Growth Factors and Microchannels

カテゴリ: 研究会(論文単位)

論文No: MAG20034,MBE20019

グループ名: 【A】基礎・材料・共通部門 マグネティックス/【C】電子・情報・システム部門 医用・生体工学合同研究会

発行日: 2020/03/19

タイトル(英語): Development of a Sensory Neuron Axon Guidance Method Utilizing Growth Factors and Microchannels

著者名: Rix Graham(Tokyo Institute of Technology),Jeon Sungha(Tokyo Institute of Technology),Miyata Hiromu(Tokyo Institute of Technology),Shimba Kenta(University of Tokyo),Miyamoto Yoshitaka(Tokyo Institute of Technology),Yagi Tohru(Tokyo Institute of Technology)

著者名(英語): Graham Rix(Tokyo Institute of Technology),Sungha Jeon(Tokyo Institute of Technology),Hiromu Miyata(Tokyo Institute of Technology),Kenta Shimba(University of Tokyo),Yoshitaka Miyamoto(Tokyo Institute of Technology),Tohru Yagi(Tokyo Institute of Technology)

キーワード: Axon Guidance|MEMS|growth factor|neuron|NGF|NT-3|Axon Guidance|MEMS|growth factor|neuron|NGF|NT-3

要約(日本語): Sensory-capable prosthetic devices are beginning to be trialled in humans, but many of the designs lack the ability to stimulate a specific sensation type. They must therefore be tested repeatedly in clinical settings in order to programme the device and to achieve adequate functionality for each recipient. Regenerative axon guidance techniques show promise in being able to reduce the training period required. We propose the use of characteristics of regenerative electrode design with specifically guided axon regeneration to control where neuron types regenerate in a device, with the goal of enabling pre-determined axon mapping in an electrode device.

要約(英語): Sensory-capable prosthetic devices are beginning to be trialled in humans, but many of the designs lack the ability to stimulate a specific sensation type. They must therefore be tested repeatedly in clinical settings in order to programme the device and to achieve adequate functionality for each recipient. Regenerative axon guidance techniques show promise in being able to reduce the training period required. We propose the use of characteristics of regenerative electrode design with specifically guided axon regeneration to control where neuron types regenerate in a device, with the goal of enabling pre-determined axon mapping in an electrode device.

原稿種別: 英語

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