培養神経細胞ネットワークにおける結合特性変化の電気刺激条件による相違

カテゴリ: 研究会(論文単位)

論文No: MBE11114

グループ名: 【C】電子・情報・システム部門 医用・生体工学研究会

発行日: 2011/09/20

タイトル(英語): The variance of connection property fluctuations in cultured neural networks according to conditions of electrical stimuli

著者名: 芳賀 達也(東京大学),深山 理(東京大学),鈴木 隆文(東京大学),満渕 邦彦(東京大学)

著者名(英語): Haga Tatsuya(The University of Tokyo),Fukayama Osamu(The University of Tokyo),Suzuki Takafumi(The University of Tokyo),Mabuchi Kunihiko(The University of Tokyo)

要約(日本語): To evaluate network plascticity induced by electrical stimuli, we recorded firings from a dissociated cortical neuronal network cultured on Multi-Electrode-array Dish (MED) in parallel with stimulation of various stimuli conditions. Six frequencies of stimuli and a choice of two single electrodes to induce stimuli were tested in the experiment. By estimating connection property at each time from data using the model-based method, the mean of connection strength was found to radically potentiate with a few frequencies of stimuli induced from only one electrode. Other stimuli conditions evoked no noticeable potentiation or depression of connection strength.

原稿種別: 日本語

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