末梢交感神経活動電位を用いた糖尿病性神経障害の評価

カテゴリ: 研究会(論文単位)

論文No: MBE11135

グループ名: 【C】電子・情報・システム部門 医用・生体工学研究会

発行日: 2011/09/21

タイトル(英語): Evaluation of diabetic neuropathy using peripheral sympathetic-nerve action potentials

著者名: 佐藤 政文(山形大学),新澤 剛(山形大学),狩俣 徹(山形大学),内藤 学(山形大学),楠 正隆(愛知医科大学),中村 孝夫(山形大学)

著者名(英語): Sato Masafumi(Yamagata University),Shinzawa Go(Yamagata University),Karimata Toru(Yamagata University),Naito Manabu(Yamagata University),Kusunoki Masataka(Aichi Medical University),Nakamura Takao(Yamagata University)

要約(日本語): To examine the possibility of evaluation of diabetic neuropathy with sympathetic nerve activity (SNA) derived microneurographically, 4 groups (Normal, STZ-3wks, STZ+ARI and STZ-1wk) of rats were used. Streptozotocin (STZ) was administered ip to each rat at 8 weeks of age in STZ-3wks and STZ+ARI groups, and at 10 weeks for STZ-1wk. Aldose reductase inhibitor (ARI) was orally given daily to STZ+ARI group after the STZ administration. At 11 weeks, sympathetic nerve signal was derived from the sciatic nerve of each rat using the microneurographic technique. After steady-state sympathetic activity was recorded, glucose was administered iv (IVGA), and the action potential (AP) rate was evaluated. The steady-state AP-rate in STZ-3wks group was lower than that in the other 3 groups. The SNA responding to IVGA gradually increased in Normal and STZ-1wk groups, whereas it showed little change in STZ-3wks and STZ-ARI groups. The results suggest that the feasibility of AP-rate in evaluating neuropathy.

原稿種別: 日本語

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