Comparison of photoacoustic signal generation characteristics of small organic molecules with various fluorescence quantum yields

カテゴリ: 研究会(論文単位)

論文No: OQD17016

グループ名: 【C】電子・情報・システム部門 光・量子デバイス研究会

発行日: 2017/03/06

タイトル(英語): Comparison of photoacoustic signal generation characteristics of small organic molecules with various fluorescence quantum yields

著者名: Takeshi Hirasawa(National Defense Medical College),Ryu J Iwatate(The University of Tokyo),Mako Kamiya(The University of Tokyo),Yuta Ikeda(National Defense Medical College),Shinpei Okawa(National Defense Medical College),Yasuteru Urano(The University of Tokyo),Miya Ishihara(National Defense Medical College)

著者名(英語): Takeshi Hirasawa(National Defense Medical College),Ryu J Iwatate(The University of Tokyo),Mako Kamiya(The University of Tokyo),Yuta Ikeda(National Defense Medical College),Shinpei Okawa(National Defense Medical College),Yasuteru Urano(The University of Tokyo),Miya Ishihara(National Defense Medical College)

キーワード: Photoacoustic imaging|Optoacoustic imaging|Multispectral|Molecular imaging|Activatable probe|Photoacoustic imaging|Optoacoustic imaging|Multispectral|Molecular imaging|Activatable probe

要約(日本語): An activatable probe which emits fluorescence only in the presence of a tumor associated enzyme γ-glutamyltranspeptidase have been successfully used in fluorescence imaging. However, fluorescence imaging can image tumors at only near surface due to blurring caused by strong optical scattering of biological tissues. To overcome this limitation, we are attempting to image activatable probes using photoacoustic (PA) imaging. To develop activatable probes for PA imaging, PA signal generation characteristics of various small organic molecules were compared. As results, all small organic molecules produced both fluorescence and PA signal, and those with small fluorescence quantum yield produced PA signals efficiently.

要約(英語): An activatable probe which emits fluorescence only in the presence of a tumor associated enzyme γ-glutamyltranspeptidase have been successfully used in fluorescence imaging. However, fluorescence imaging can image tumors at only near surface due to blurring caused by strong optical scattering of biological tissues. To overcome this limitation, we are attempting to image activatable probes using photoacoustic (PA) imaging. To develop activatable probes for PA imaging, PA signal generation characteristics of various small organic molecules were compared. As results, all small organic molecules produced both fluorescence and PA signal, and those with small fluorescence quantum yield produced PA signals efficiently.

原稿種別: 英語

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