ラット脳内の多点電位計測にもとづく局所磁場分布の推定

カテゴリ: 論文誌(論文単位)

グループ名: 【A】基礎・材料・共通部門

発行日: 2013/06/01

タイトル(英語): Estimation of Local Magnetic Fields in the Rat Brain based on Multichannel Potential Recordings

著者名: 武輪　知明（東京大学 大学院工学系研究科 電気系工学専攻），キム　ドンミン（JST ERATO 染谷生体調和エレクトロニクスプロジェクト），井上　雄介（JST ERATO 染谷生体調和エレクトロニクスプロジェクト），大崎　博之（東京大学　大学院新領域創成科学研究科 先端エネルギー工学専攻），関野　正樹（東京大学 大学院工学系研究科 電気系工学専攻）

著者名(英語): Tomoaki Takewa (Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo), Dongmin Kim (JST ERATO Someya Bio-Harmonized Electronics Project), Yusuke Inoue (JST ERATO Someya Bio-Harmonized Electronics Project), Hiroyuki Ohsaki (Department of Advanced Energy, Graduate School of Frontier Sciences, The University of Tokyo), Masaki Sekino (Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo)

キーワード: 磁気共鳴画像，微小電極アレイ，神経電気活動，微弱磁場，体性感覚誘発電位　　magnetic resonance imaging，microelectrode array，neuronal electrical activities，weak magnetic field，somatosensory evoked potential

要約(英語): Conventional functional magnetic resonance imaging (MRI) has a relatively low temporal resolution, because this method does not measure neuronal activity itself but observes blood flow. The detection of local magnetic fields in close proximity to the activating area leads to a novel functional MRI with ultrahigh temporal resolution. Magnetic fields arising from neuronal electrical activities are very weak.The aim of this study is to evaluate the feasibility of detecting neuronal magnetic fields using MRI. The three-dimensional potential distribution in the rat brain was measured using a microelectrode array. Somatosensory evoked potentials were recorded during hind paw stimulation with a spatial resolution of 300μm. The intensity of the magnetic flux density was calculated from the measured result, and was estimated at 2.84pT.Estimation of the theoretical limit of MRI sensitivity suggested that the calculated magnetic flux density was within the detectable range of MRI.

本誌: 電気学会論文誌A（基礎・材料・共通部門誌） Vol.133 No.6 （2013） 特集：磁気を用いた医療・医用応用技術

本誌掲載ページ: 376-382 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejfms/133/6/133_376/_article/-char/ja/