波長388nm及び775nmのフェムト秒レーザーにより形成した周期的微細構造が細胞伸展に与える効果

カテゴリ: 論文誌(論文単位)

グループ名: 【A】基礎・材料・共通部門

発行日: 2015/10/01

タイトル(英語): Effect of Periodic Nanostructures Produced with Femtosecond Laser for Wavelength of 388 and 775 nm on Cell Spreading

著者名: 篠永　東吾（岡山大学大学院自然科学研究科），塚本　雅裕（大阪大学接合科学研究所），陳　鵬（東京医科歯科大学生体材料工学研究所），塙　隆夫（東京医科歯科大学生体材料工学研究所）

著者名(英語): Togo Shinonaga (Graduate School of Natural Science and Technology, Okayama University), Masahiro Tsukamoto (Joining and Welding Research Institute, Osaka University), Peng Chen (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University), Takao Hanawa (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University)

キーワード: フェムト秒レーザー，周期的微細構造，酸化チタン膜，細胞伸展，骨芽細胞　　femtosecond laser，periodic nanostructures，titanium dioxide film，cell spreading，osteoblast

要約(英語): Titanium (Ti) is one of the most used biomaterials. However, it has problem for biocompatibility. Adding new function to Ti surface is necessary. Coating of titanium dioxide (TiO2) film on Ti surface is a useful method for improving the biocompatibility of Ti. We have a film coating method with an aerosol beam. Control of cell spreading by periodic nanostructures formation with femtosecond laser is also useful method for adding new function to TiO2 film. The control of cell spreading is important for the development of advanced biomaterials. In this study, the periodic nanostructures with periods of 130 and 230 nm were formed on a film using a femtosecond laser with wavelengths of 388 and 775 nm, respectively. Effect of periods on cell spreading was investigated. Cell tests showed that cells spread along the grooves of the periodic nanostructures with periods of 130 and 230 nm, whereas cell spreading did not have a definite direction on a film without periodic nanostructures. Distribution of angle of cell spreading on laser irradiated area was examined. These results suggested that controlling the cell spreading on periodic nanostructures with period of 230 nm was better than that of 130 nm.

本誌: 電気学会論文誌A（基礎・材料・共通部門誌） Vol.135 No.10 （2015） 特集：光エネルギー応用技術の最新動向

本誌掲載ページ: 587-591 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejfms/135/10/135_587/_article/-char/ja/