がん細胞に対するナノ秒パルス電界と抗がん剤の併用効果

カテゴリ: 論文誌(論文単位)

グループ名: 【A】基礎・材料・共通部門

発行日: 2021/12/01

タイトル(英語): Effects of Nanosecond Pulsed Electric Fields Application on Cancer Cell and Combination of Anticancer Drug

著者名: 榎本　壮一郎（徳島大学），小西　大輔（徳島大学），宇都　義浩（徳島大学），下村　直行（徳島大学）

著者名(英語): Soichiro Enomoto (Tokushima University), Daisuke Konishi (Tokushima University), Yoshihiro Uto (Tokushima University), Naoyuki Shimomura (Tokushima University)

キーワード: ナノ秒パルス電界，ナノポレーション，がん治療，抗がん剤，相乗効果　　nsPEFs，nanoporation，cancer treatment，anti-cancer drug，synergy

要約(英語): With the goal of establishing a new cancer treatment method using nanosecond pulsed electric fields (nsPEFs), we investigated the effect of applying nsPEFs and anticancer drugs (adriamycin, ADM) to cancer cells. The surviving fraction of cancer cells was significantly reduced by nsPEFs application compared to the control. Compared to nsPEFs alone and ADM administration alone, a significant decrease of the surviving fraction was observed in combination of nsPEFs application and ADM administration. In addition, multiplying value of surviving fractions of nsPEFs application and ADM administration was calculated as a pseudo-combination effect. The surviving fractions of the experimental combinational results of nsPEFs and ADM were lower than the pseudo-combination results. Therefore, the synergistic effect of combination of nsPEFs and ADM was confirmed. Furthermore, the surviving fraction of ADM administration after nsPEFs application was significantly lower than that of ADM administration on 24 hours before nsPEFs application. ADM action on cells would be effective owing to nanopores were formed by applying nsPEFs. It was confirmed that ADM and nsPEF induced apoptosis of cells from apoptosis and necrosis test using FACS.

本誌: 電気学会論文誌A（基礎・材料・共通部門誌） Vol.141 No.12 （2021）

本誌掲載ページ: 657-664 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejfms/141/12/141_657/_article/-char/ja/