腫瘍の低酸素イメージングと酸素化過程における時空間解析

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2012/10/01

タイトル(英語): Hypoxia Imaging of Tumor and Spatiotemporal Analysis during Oxygen Inhalation

著者名: 山田　遼（慶應義塾大学大学院 理工学研究科 基礎理工学専攻），堀之内　宏久（慶應義塾大学 医学部 呼吸器外科），塚田　孝祐（慶應義塾大学大学院 理工学研究科 基礎理工学専攻／慶應義塾大学 理工学部 物理情報工学科）

著者名(英語): Ryo Yamada (Graduate School of Fundamental Science and Technology, Keio University), Hirohisa Horinouchi (Division of general Thoracic Surgery, School of Medicine, Keio University), Kosuke Tsukada (Graduate School of Fundamental Science and Technology, Keio University/Department of Applied Physics and Physico-Informatics, Keio University)

キーワード: 酸素分圧，腫瘍，微小循環，放射線治療　　Oxygen tension，Tumor，Microcircultion，Radiation Therapy

要約(英語): Tumor hypoxia is considered a potential therapeutic problem because it reduces the effects of radiation therapy. Clinical experience has shown that long-term tumor oxygenation cannot be achieved with oxygen inhalation, but the mechanisms behind this phenomenon remain unknown. In this study, we designed an optical system for evaluating spatiotemporal changes in tissue oxygen tension (pO2) by phosphorescence quenching. The system can measure continuous changes in pO2 at a fixed point and can also perform two-dimensional mapping of pO2 in any part of the tumor tissue. We implanted tumor tissue in a dorsal skinfold chamber of C57BL/6 mice and observed tumor growth. The mice received oxygen inhalation and pO2 was measured. Tumor pO2 increased after inhalation but the oxygen level was not maintained despite continuous inhalation of pure oxygen; the tumor returned to a hypoxic state. These results mimic the clinical experience of oxygen inhalation treatment in radiation therapy. Our system reproduces the repeat hypoxic phenomenon in a murine tumor model and can be used to determine the mechanisms of oxygen metabolism in tumors.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.132 No.10 （2012） 特集：医療関連電子技術のニュートピック

本誌掲載ページ: 1602-1607 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/132/10/132_1602/_article/-char/ja/