血中アルコール濃度の非侵襲光学的計測法確立に向けた基礎的検討―近赤外領域における希薄エチルアルコール溶液濃度の定量化―

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2012/12/01

タイトル(英語): Towards Non-invasive Optical Blood Alcohol Measurement: Multi-variate Analysis of in vitro NIR Spectra

著者名: 山越　健弘（金沢大学　大学院自然科学研究科），小川　充洋（金沢大学　理工研究域機械工学系），松村　健太（金沢大学　理工研究域機械工学系），宮崎　慎平（金沢大学　大学院自然科学研究科），板坂　優希（金沢大学　大学院自然科学研究科），井田　孝之（金沢大学　大学院自然科学研究科），山越　康弘（(株) ユーシス），廣瀬　元（金城大学短期大学部　ビジネス実務学科），山越　憲一（金沢大学　理工研究域機械工学系）

著者名(英語): Takehiro Yamakoshi (Graduate School of Natural Science and Technology, Kanazawa University), Mitsuhiro Ogawa (College of Science and Engineering, Kanazawa University), Kenta Matsumura (College of Science and Engineering, Kanazawa University), Shimpei Miyazaki (Graduate School of Natural Science and Technology, Kanazawa University), Yuki Itasaka (Graduate School of Natural Science and Technology, Kanazawa University), Takayuki Ida (Graduate School of Natural Science and Technology, Kanazawa University), Yasuhiro Yamakoshi (yu.sys Corporation), Hajime Hirose (Department of Business Administration, Kinjo College), Ken-ichi Yamakoshi (College of Science and Engineering, Kanazawa University)

キーワード: エチルアルコール，近赤外分光法，重回帰分析，非侵襲生体計測　　ethyl alcohol，near infra-red spectroscopy，multiple linier regression analysis，non-invasive measurement

要約(英語): The long-term aim of our research is to develop near infra-red spectroscopy for non-invasive measurement of blood alcohol concentrations. The absorption spectrum of ethyl-alcohol could possibly provide the means for such an approach, but the absorption bands of other molecules, such as glucose and acetaldehyde, together with the very low in vivo ethyl-alcohol concentrations (EAC), represent significant analytical challenges. Here we present results of our in vitro investigation of ethyl-alcohol absorption spectra, and the use of multiple linear regression analysis to predict EAC in the presence of glucose and acetaldehyde. We used ethyl-alcohol and mixed solutions of ethyl-alcohol, glucose, and acetaldehyde. The latter were divided into three experimental systems as ethyl-alcohol/glucose, ethyl-alcohol/acetaldehyde, and ethyl-alcohol/glucose/acetaldehyde solutions. The range of EAC used was the same as that found in blood. The results showed good correlation between the actual EAC and the predicted EAC (control; R=0.99, mean absolute error (MAE)=0.12mg/ml: glucose system; R=0.97, MAE=0.18mg/ml: acetaldehyde system; R=0.99, MAE=0.23mg/ml: glucose & acetaldehyde system; R=0.98, MAE=0.19mg/ml). We conclude that the change of glucose and acetaldehyde concentration does not measurably affect the absorption bands of ethyl-alcohol.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.132 No.12 （2012） 特集：電気関係学会東海支部連合大会

本誌掲載ページ: 2059-2064 p

原稿種別: 資料／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/132/12/132_2059/_article/-char/ja/