培養神経回路網における誘発応答パターンの履歴現象

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2013/10/01

タイトル(英語): Hysteresis of Evoked Activity Pattern in a Cultured Neuronal Network

著者名: 伊東　嗣功（関西学院大学 理工学研究科 人間システム工学），工藤　卓（関西学院大学 理工学研究科 人間システム工学）

著者名(英語): Hidekatsu Ito (Department of Infomatics, School of Science and Technology, Kwansei Gakuin University), Suguru Kudoh (Department of Infomatics, School of Science and Technology, Kwansei Gakuin University)

キーワード: 分散培養，多点電極アレイ，ネットワークダイナミクス，履歴現象　　Dissociated Culture，MEA，Network Dynamics，Hysteresis

要約(英語): Cultured neurons reconstruct a neuronal network on a culture dish. The network structure is modified by input from outer world in activity dependent manner. Cultured rat hippocampal neurons on a multielectrodes array (MEA) dish are suitable for analyzing such complex network dynamics and developmental processes of network formation. To elucidate network dynamics, we applied shots of electrical stimuli in several types of inter-stimulus intervals. The electrical activity pattern of the living neuronal network evoked by paired stimulation is quite different from one evoked by a single stimulation. In this report, the feature of this type of network hysteresis was investigated and the hysteresis was kept for at least 1 s and not kept for 10 s. In addition, this hysteresis was remarkable only in long cultures with matured complex networks.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.133 No.10 （2013） 特集：分散エネルギーマネジメント

本誌掲載ページ: 1905-1911 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/133/10/133_1905/_article/-char/ja/