現実およびバーチャルリアリティ空間を用いたマウス用行動課題訓練システムの確立

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2014/07/01

タイトル(英語): Automated Training Systems in Real and Virtual Worlds for Tactile Discrimination Learning in Mice

著者名: 本間　千尋（（独）理化学研究所脳科学総合研究センター），鴨志田　敦史（（独）理化学研究所脳科学総合研究センター／日本ナショナルインスツルメンツ（株）），鈴木　崇之（（独）理化学研究所脳科学総合研究センター），織田　充（（独）理化学研究所脳科学総合研究センター），山川　宏（（独）理化学研究所脳科学総合研究センター），山田　一之（（独）理化学研究所脳科学総合研究センター），村山　正宜（（独）理化学研究所脳科学総合研究センター）

著者名(英語): Chihiro Homma (Brain Science institute (BSI), RIKEN), Atsushi Kamoshida (Brain Science institute (BSI), RIKEN/National Instruments Japan Corporation), Takayuki Suzuki (Brain Science institute (BSI), RIKEN), Mitsuru Oda (Brain Science institute (BSI), RIKEN), Hiroshi Yamakawa (Brain Science institute (BSI), RIKEN), Kazuyuki Yamada (Brain Science institute (BSI), RIKEN), Masanori Murayama (Brain Science institute (BSI), RIKEN)

キーワード: 体性感覚，弁別学習，Y迷路，バーチャルリアリティ空間，自動化　　somatosensory，discrimination learning，Y-maze，virtual reality world，automated

要約(英語): Somatic sensations are thought to be represented by the neural activity in the primary somatosensory cortex (S1), which can then be used for higher brain functions, such as decision-making, and memory. However, it is still unclear how neural activity represents these sensations and contributes to those functions. In a previous study, we showed that the intensity of limb stimulation in awake rodents could be coded by dendritic activity of layer 5 pyramidal neurons in S1(1). This implies that somatosensation of tactile stimuli can also be used as a primary mode of input for higher brain areas. To understand causal relationship between S1 activity and higher brain functions, we developed a new experimental system in which mice discriminated texture in a modified Y-maze. With this maze, mice were successfully trained to discriminate a specific tactile stimulus on the floor of the maze at an area just before the branch point. On the basis of these results, we designed a task in virtual world situations. This system also can present tactile stimulation while mice are running within the maze. Now, we are using this system for electrophysiological and optogenetic experiments, and trying to gain new knowledge in the field of neurobehavioral research.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.134 No.7 （2014） 特集：平成25年電子・情報・システム部門大会

本誌掲載ページ: 904-908 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/134/7/134_904/_article/-char/ja/