高効率LEDによる光照射とビリルビン添加による白血病細胞増殖抑制

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2014/11/01

タイトル(英語): Inhibition of Leukemia Cell Proliferation using High Power LED Irradiation and Bilirubin Administration

著者名: 白井　僚（香川大学大学院工学研究科電子・情報工学専攻），岡本　研正（香川大学大学院工学研究科電子・情報工学専攻），服部　哲郎（香川大学大学院工学研究科電子・情報工学専攻），平田　裕子（香川大学大学院医学研究科細胞情報生理学教室），山口　文徳（香川大学大学院医学研究科細胞情報生理学教室），徳田　雅明（香川大学大学院医学研究科細胞情報生理学教室）

著者名(英語): Ryo Shirai (School of Engineering, Department of Electronics, Kagawa University), Kensho Okamoto (School of Engineering, Department of Electronics, Kagawa University), Tetsuo Hattori (School of Engineering, Department of Electronics, Kagawa University), Yuko Hirata (School of Medicine, Laboratory of Cell Physiology, Kagawa University), Fuminori Yamaguchi (School of Medicine, Laboratory of Cell Physiology, Kagawa University), Masaaki Tokuda (School of Medicine, Laboratory of Cell Physiology, Kagawa University)

キーワード: LED，光線力学療法，白血病，ビリルビン　　LED，photo dynamic therapy，leukemia，bilirubin

要約(英語): Recently, phototherapy which utilizes artificial light source like laser and light-emitting diode (LED) has attracted much attention. Among such phototherapies, photodynamic therapy (PDT) is well-known and used in hospitals to cure cancer. The PDT is utilized for lung cancer and skin disease and it combines a photosensitive agent, e.g. Photofrin or Laserphyrin, and laser with a particular wavelength. In this research, we noticed the bilirubin as a photosensitive agent. The bilirubin has a photosensitivity and exists in human body as a metabolite of blood. Experiments were carried out in vitro to inhibit leukemia cells using high efficiency LED light irradiation and bilirubin administration. Experimental results showed that the activated bilirubin by blue LED light irradiation remarkably suppressed the proliferation of leukemia cells in the culture vessel. This fact may pave a new way to natural cure using sunlight or artificial light for leukemia therapy.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.134 No.11 （2014） 特集Ⅰ：電気関係学会関西連合大会　特集Ⅱ：国際会議ヒューマナイズド　システム2013

本誌掲載ページ: 1603-1612 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/134/11/134_1603/_article/-char/ja/