音響外傷が聴覚野の定常的な神経活動の位相同期に及ぼす影響

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2015/07/01

タイトル(英語): Effect of Acoustic Trauma on Phase Synchrony of Steady-state Activity in the Rat Auditory Cortex

著者名: 和家　尚希（東京大学大学院情報理工学系研究科），白松(磯口)　知世（東京大学先端科学技術研究センター），神崎　亮平（東京大学先端科学技術研究センター），高橋　宏知（東京大学先端科学技術研究センター）

著者名(英語): Naoki Wake (Graduate School of Information Science and Technology, The University of Tokyo), Tomoyo Shiramatsu (Isoguchi) (Research Center for Advanced Science and Technology, The University of Tokyo), Ryohei Kanzaki (Research Center for Advanced Science and Technology, The University of Tokyo), Hirokazu Takahashi (Research Center for Advanced Science and Technology, The University of Tokyo)

キーワード: 音響外傷，難聴，聴覚野，位相同期，微小電極アレイ　　Acoustic trauma，Hearing loss，Auditory cortex，Phase synchrony，Microelectrode array

要約(英語): Exposure to a high intensity sound damages the inner ear, leading to hearing loss and tinnitus. Previous studies have found that such acoustic trauma also changes neural activities in the auditory cortex. However, to the best of our knowledge, no study investigated the effect of acoustic trauma on the synchrony of steady-state activities in the auditory cortex. In this study, at pre- and post-exposure of an intense sound (16 kHz pure tone; 96 dB SPL; 90 minutes), we investigated Phase Locking Value (PLV) to measure the synchrony of the activities in the auditory cortex of anesthetized rats. Acoustic trauma was confirmed by the auditory brainstem responses (ABR) exhibiting reduced amplitude and prolonged latency. Consequently, we found decreased PLV during presentation of continuous pure tones. In addition, we found an increased contrast of θ-band PLV between silence and tone presentation conditions. These results suggest that an acoustic trauma changes the representation of sound in the auditory cortex in terms of the steady-state phase synchrony.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.135 No.7 （2015） 特集：平成26 年電子・情報・システム部門大会

本誌掲載ページ: 832-838 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/135/7/135_832/_article/-char/ja/