膵臓β細胞内インスリン顆粒動態シミュレーション・モデル

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2015/08/01

タイトル(英語): Simulation Model of Insulin Granule Dynamics in Pancreatic Beta Cell

著者名: 松本　卓也（神戸大学大学院システム情報学研究科），田畑　直紀（神戸大学大学院システム情報学研究科），玉置　久（神戸大学大学院システム情報学研究科），柴崎　忠雄（神戸大学大学院医学研究科），清野　進（神戸大学大学院医学研究科），須永　泰弘（理化学研究所），横田　秀夫（理化学研究所），福島　光夫（岡山県立大学）

著者名(英語): Takuya Matsumoto (Graduate School of System Informatics, Kobe University), Naoki Tabata (Graduate School of System Informatics, Kobe University), Hisashi Tamaki (Graduate School of System Informatics, Kobe University), Tadao Shibasaki (Graduate School of Medicine, Kobe University), Susumu Seino (Graduate School of Medicine, Kobe University), Yasuhiro Sunaga (RIKEN), Hideo Yokota (RIKEN), Mitsuo Fukushima (Okayama Prefectural University)

キーワード: シミュレーション，モデル化，インスリン顆粒，膵臓β細胞　　Simulation，Modeling，Insulin Granules，Pancreatic Beta Cell

要約(英語): Insulin secretion from pancreatic β cells plays the central role in maintaining glucose homeostasis. Impaired insulin secretion mainly contributes to the pathogenesis and pathophysiology of type 2 diabetes mellitus. Diabetes of the type-2, which are typical among Asian patients, are caused by insufficient insulin secretions by unknown factors. For revealing the factors and dealing with them properly, it is necessary to clarify the insulin secretion mechanism in pancreatic β cells. In insulin granule kinetics, i.e. the transportation process of insulin granules produced in pancreatic β cells to the cell membrane for secretion, the granules are supposed to move along the cytoskeleton. For constructing the simulation model, we divided the model into four stages based on the skeleton of a pancreatic β cell and the principle of granule kinetics, i.e., the granule producing site, the inner layer, the outer layer and the granule secretory part. The phenomena to be reproduced are the typical secretion patterns found in healthy person, diabetic patients and healthy person with incretins. In this paper, a series of simulations based on the data concerning insulin granules kinetics have been carried out, where the typical secretion patterns have been reproduced by setting the parameters adequately according to the observation in a pancreatic β cell without changing the model itself. Through these simulation results, the potential of the proposed model has been confirmed.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.135 No.8 （2015） 特集：知能メカトロニクス分野と連携する知覚情報技術

本誌掲載ページ: 963-970 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/135/8/135_963/_article/-char/ja/