迷走神経刺激がラット聴皮質における順応反応に及ぼす影響

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2015/09/01

タイトル(英語): Effects of Vagus Nerve Stimulation on Neural Adaptation in Rat Auditory Cortex

著者名: 日露　理英（東京大学大学院情報理工学系研究科），白松（磯口）　知世（東京大学先端科学技術研究センター），野田　貴大（東京大学先端科学技術研究センター），神崎　亮平（東京大学先端科学技術研究センター），宇野　健志（東京大学大学院医学系研究科），川合　謙介（NTT東日本関東病院），高橋　宏知（東京大学大学院情報理工学系研究科／東京大学先端科学技術研究センター）

著者名(英語): Rie Hitsuyu (Graduate School of Information Science and Technology, The University of Tokyo), Tomoyo Isoguchi Shiramatsu (Research Center for Advanced Science and Technology, The University of Tokyo), Takahiro Noda (Research Center for Advanced Science and Technology, The University of Tokyo), Ryohei Kanzaki (Research Center for Advanced Science and Technology, The University of Tokyo), Takeshi Uno (Graduate School of Medicine, The University of Tokyo), Kensuke Kawai (NTT Medical Center Tokyo), Hirokazu Takahashi (Graduate School of Information Science and Technology, The University of Tokyo/Research Center for Advanced Science and Technology, The University of Tokyo)

キーワード: 迷走神経刺激，聴覚野，順応，多点電極，ラット　　vagus nerve stimulation，auditory cortex，neural adaptation，microelectrode array，rat

要約(英語): Vagus nerve stimulation (VNS) causes neuromodulatory effects in the cerebral cortex, which are useful not only for therapy on intractable epilepsy but also for enhancement of higher brain functions such as cognition and memory. Recently, it has been reported that VNS may also affect auditory-evoked neural activities. However, it remains to be elucidated how and where VNS modulates neural activities in the auditory cortex. Here we examined effects of VNS on adaptation of neural activities in response to repeated stimuli in the rat auditory cortex. Both a surface and depth microelectrode array recorded auditory evoked potentials in response to click trains and oddball stimuli. We quantified a repetition rate transfer function (RRTF) and common stimulus-specific adaptation (SSA) index (CSI) from the amplitude of middle-latency response (P1). Consequently, VNS affected temporal response property and increased SSA in the layer 1 and 5/6 of auditory cortex. This result suggests that VNS strengthens adaptation in the auditory cortex in a layer-specific manner.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.135 No.9 （2015） 特集：サステナブル社会・先端応用へ向けたレーザプロセシング技術

本誌掲載ページ: 1112-1119 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/135/9/135_1112/_article/-char/ja/