蛍光信号を利用したゲノム・生体情報の測定手法の現状と展望

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2017/04/01

タイトル(英語): A Mini Review of Methods for Acquiring Genomic/Biological Information using Fluorescent Signal: Current Status and Future Prospects

著者名: 稻岡　秀檢（北里大学医療衛生学部）

著者名(英語): Hidenori Inaoka (Allied Health Sciences, Kitasato University)

キーワード: 網羅的測定，超解像蛍光顕微鏡法，全身イメージング　　comprehensive measurement，super resultion fluorescence microscopy，whole body imaging

要約(英語): Genomic/Biological information has been measured over a wide range of spatial resolution: 1) micro-size level (e.g. gene expression, DNA methylation, chromosomal territory), 2) single cellar level (e.g. intracellular transmission, signal processing between protein and membrane), 3) small cell population level (e.g signal processing in cells), 4) tissue-size level (e.g. development or metastasis of tumor), 5) whole-body level (e.g drug delivery system).Data acquiring technique using fluorescence imaging has been intensively studied. The fluorescent probe binds specific DNA sequence in nucleus or specific protein in a cell, and the probe labels target location specifically. Furthermore, improved fluorescent light of longer wavelength provides imaging information on deeper parts of the whole body.This paper focuses on the fluorescence imaging methods such as super resolution fluorescence microscopy, fluorescence in situ hybridization, and deep imaging. Both of the microscopic imaging and the macroscopic imaging are discussed in detail.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.137 No.4 （2017） 特集：量子・情報・エレクトロニクス医療応用

本誌掲載ページ: 552-560 p

原稿種別: 解説／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/137/4/137_552/_article/-char/ja/