時間分解分光法によるヘモグロビン濃度の推定とBOLD信号との定量的比較

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2018/07/01

タイトル(英語): A Quantitative Comparison of Hemoglobin Concentration and BOLD Signal using Time-Resolved Near-Infrared Spectroscopy

著者名: 庭野　恭彰（東京大学大学院 工学系研究科），赤尾　旭彦（東京大学大学院 工学系研究科），四本　裕子（東京大学大学院 総合文化研究科），神保　泰彦（東京大学大学院 工学系研究科），小谷　潔（東京大学大学院 工学系研究科／東京大学先端科学技術研究センター／独立行政法人科学技術振興機構 さきがけ）

著者名(英語): Yasuaki Niwano (Graduate School of Engineering, The University of Tokyo), Akihiko Akao (Graduate School of Engineering, The University of Tokyo), Yuko Yotsumoto (Graduate School of Arts and Science, The University of Tokyo), Yasuhiko Jimbo (Graduate Schoo

キーワード: 時間分解分光法，機能的磁気共鳴画像法，ワーキングメモリ　　time-resolved spectroscopy，functional magnetic resonance imaging，working memory

要約(英語): Time-Resolved Near-Infrared Spectroscopy (TR-NIRS) is a method of analyzing the time response of the reflected light using a light diffusion equation, and enables us to measure the hemoglobin (Hb) absolute concentration, In this research, we evaluated the applicability of TR-NIRS for the measurement of brain activity. First, we conducted the simultaneous measurement of Continuous Wave Near-Infrared spectroscopy (CW-NIRS) and TR-NIRS in the working memory tasks. The results show the conventional analysis is not applicable, because the fluctuation is larger than the task-related change. Second, we proposed a new signal processing method for suppressing the fluctuation and examined the validity in the original fantom. Finally, by using the proposed method, we conducted the simultaneous measurement of TR-NIRS and functional MRI (fMRI) in the working memory tasks, and verify depth of reach and light path of near infrared light. The result suggests that we can estimate the Hb concentration due to brain activity using the proposed method.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.138 No.7 （2018）特集：平成29年電子・情報・システム部門大会

本誌掲載ページ: 790-798 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/138/7/138_790/_article/-char/ja/