神経細胞の分散培養系における集団同期発火パターンとネットワーク構造の発達

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2019/05/01

タイトル(英語): Development of Network Structure and Synchronized Firing Patterns in Dissociated Culture of Neurons

著者名: 鹿山　敦至（東京大学大学院情報理工学系研究科），矢田　祐一郎（理化学研究所バイオリソース研究センター／東京大学先端科学技術研究センター），高橋　宏知（東京大学大学院情報理工学系研究科／東京大学先端科学技術研究センター）

著者名(英語): Atsushi Kayama (Graduate School of Information Science and Technology, The University of Tokyo), Yuichiro Yada (RIKEN BRC/Research Center for Advanced Science and Technology, The University of Tokyo), Hirokazu Takahashi (Graduate School of Information Science and Technology, The University of Tokyo/Research Center for Advanced Science and Technology, The University of Tokyo)

キーワード: 初代分散培養，神経細胞，発達，微小電極アレイ，移送エントロピー　　primary dissociated cultures，neurons，development，microelectrode array (MEA)，transfer entropy

要約(英語): Spatio-temporal patterns of neural activities develop repeatability, diversity, and hierarchy. In the present study, we attempted to elucidate how these dynamical properties are associated with a network structure in primary cultures of dissociated neurons. High-density CMOS electrode array investigated spatio-temporal activity patterns of dissociate neuronal cultures throughout development. Additionally, based on the spatio-temporal patterns in each test culture, a structure of functional network was estimated with transfer entropy in a pairwise manner. Consequently, repeatability increased with connection strength, dispersity, and clustering at the early developmental stage. Subsequently, hierarchy developed with connection strength and dispersity. These results demonstrated that a repertoire of activity patterns developed with some characteristics of network structure.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.139 No.5 （2019） 特集Ⅰ：電子・情報・システム技術とものづくり　特集Ⅱ：生体を診る・解く・支える技術

本誌掲載ページ: 570-578 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/139/5/139_570/_article/-char/ja/