単一桿体視細胞の光応答シミュレーション解析

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2021/03/01

タイトル(英語): Simulation Analysis of the Photoresponse in Retinal Rods

著者名: 山下　茜（愛知県立大学大学院 情報科学研究科），神山　斉己（愛知県立大学大学院 情報科学研究科）

著者名(英語): Akane Yamashita (Graduate School of Information Science and Technology, Aichi Prefectural University), Yoshimi Kamiyama (Graduate School of Information Science and Technology, Aichi Prefectural University)

キーワード: 桿体視細胞，数理モデル，シミュレーション解析　　rod，computational model，simulation analysis

要約(英語): Retinal rod photoreceptors in the eyes play a role in the first steps of the visual information processing and convert light into neural signals. In recent years, mathematical models of phototransduction mechanism in the outer segment(OS) of the rod have been developed and applied to analyze the biophysical processes. Although the membrane potential is responsible for sending messages to second order neurons generated in the inner segment(IS), the membrane electrical properties of IS have not been well modeled yet.In this study, in order to clarify the function of the rod, we integrate the multiscale properties into a model. The model is based on the previous studies, i.e., the model of the OS (Dell'Orco et al.) and the model of the IS (Kamiyama et al., Publio et al.). To evaluate the model, the photocurrent in the OS and photovoltage in the IS were analyzed under a variety of conditions, including effects by channel blockers and the mutaion of retinal pigment epithelium (RPE). As a result, the model reproduced the photoresponses observed in the previous studies.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.141 No.3 （2021） 特集：スマートシステムと計測・制御技術 －超スマート社会に向けて－

本誌掲載ページ: 402-407 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/141/3/141_402/_article/-char/ja/