Functional Analysis of Liposomes Containing Single-Walled Carbon Nanotubes (SWNTs) by Fluorescence Microscopy

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2021/05/01

タイトル(英語): Functional Analysis of Liposomes Containing Single-Walled Carbon Nanotubes (SWNTs) by Fluorescence Microscopy

著者名: Shoichiro Kanno (Tokyo Institute of Technology), Zugui Peng (Tokyo Institute of Technology), Kenta Shimba (The University of Tokyo), Yoshitaka Miyamoto (National Center for Child Health and Development), Tohru Yagi (Tokyo Institute of Technology)

著者名(英語): Shoichiro Kanno (Tokyo Institute of Technology), Zugui Peng (Tokyo Institute of Technology), Kenta Shimba (The University of Tokyo), Yoshitaka Miyamoto (National Center for Child Health and Development), Tohru Yagi (Tokyo Institute of Technology)

キーワード: liposome，carbon nanotube

要約(英語): Single-walled carbon nanotubes (SWNTs) are hollow cylinder-shaped carbon materials through which ions and some small molecules can pass with high permeability. Hence, SWNTs have attracted great interest for their potential application in spherical artificial biomembranes (liposomes) used to filter substances. Mass transport processes through SWNTs are currently measured based on changes in the fluorescence intensity of fluorescent probes in liposomes. However, it is difficult to determine whether the change in fluorescence intensity is due to SWNTs or to destruction of the liposome in small liposomes (<200 nm diameter). Accordingly, the mechanism of the transport process remains unclear. Therefore, in this study, we propose a new approach to observing the transport process through SWNTs by embedding SWNTs in liposomes over 10 μm in diameter (giant liposomes). The large size of the liposomes allows easy observation of their shape under a microscope. The experimental results indicate that the ion permeation and transport processes of SWNTs can be indirectly observed using giant liposomes and a fluorescence microscope.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.141 No.5 （2021） 特集：神経工学

本誌掲載ページ: 620-626 p

原稿種別: 論文／英語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/141/5/141_620/_article/-char/ja/