視床刺激が聴知覚に及ぼす影響を評価する実験系の構築

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2021/05/01

タイトル(英語): Experimental System to Evaluate Auditory Perception Induced by Microstimulation of Auditory Thalamus of Rats

著者名: 白松(磯口)　知世（東京大学大学院情報理工学系研究科），阿部　泰己（東京大学大学院情報理工学系研究科），石津　光太郎（東京大学定量生命科学研究所），高橋　宏知（東京大学大学院情報理工学系研究科）

著者名(英語): Tomoyo Isoguchi Shiramatsu (Graduate School of Information Science and Technology, The University of Tokyo), Taiki Abe (Graduate School of Information Science and Technology, The University of Tokyo), Kotaro Ishizu (Institute for Quantitave Bioscience, Th

キーワード: 聴知覚，聴覚野，視床，微小電極アレイ，電気刺激，ラット　　auditory perception，auditory cortex，thalamus，microelectrode array，microstimulation，rat

要約(英語): Electrical stimulation of the auditory nerves is well known to provide auditory perception, while it remains to be elucidated whether the microstimulation of the auditory thalamus generate or modulate auditory perception. Herein, we established a novel experimental system to evaluate effects of thalamic microstimulation on auditory perception in both behavioral and electrophysiological manners; we conditioned rats to report their auditory perception by pulling a lever, then recorded their behavior and cortical activities when we provided sound stimuli, or thalamic microstimulation, or co-stimulation of them. Consequently, one of the three tested animals reported a putative auditory perception by lever-pulling behavior in response to the thalamic microstimulation with strong pulse current. In addition, co-stimulation using microstimulation with strong or weak pulse current increased or decreased its lever-pulling activity, respectively. Finally, the microelectrode mapping revealed that the microstimulation with strong pulse current induced positive shift of the surface potential inside the auditory cortex. These results suggest that the microstimulation to thalamus affect auditory perception by modulating cortical activity, and that the present experimental system will contribute to elucidating neural mechanisms of auditory prosthesis.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.141 No.5 （2021） 特集：神経工学

本誌掲載ページ: 627-633 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/141/5/141_627/_article/-char/ja/