低頻度刺激による神経細胞の分散培養系の学習

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2021/05/01

タイトル(英語): Learning in Dissociated Neuronal Cultures by Low-frequency Stimulation

著者名: 池田　成満（東京大学大学院情報理工学系研究科），高橋　宏知（東京大学大学院情報理工学系研究科）

著者名(英語): Narumitsu Ikeda (Graduate School of Information Science and Technology, The University of Tokyo), Hirokazu Takahashi (Graduate School of Information Science and Technology, The University of Tokyo)

キーワード: 神経回路，可塑性，自発活動，微小電極アレイ，相互情報量　　neuronal networks，plasticity，spontaneous activity，microelectrode array，mutual information

要約(英語): High-frequency stimulation that induces long-term potentiation (LTP), rather than low-frequency stimulation that induces long-term depression (LTD), is usually used to induce stimulus-specific plasticity in neural systems. Here, we demonstrated in dissociated neuronal cultures that low-frequency stimulation induced stimulus-specific plasticity with a longer time scale than high-frequency stimulation. In the training session, 1-Hz low-frequency electrical stimulation with specific spatial patterns was applied for 1 h to induce plasticity in dissociated neurons on a high-density microelectrode array. Evoked discharges of neurons reduced immediately after the training session, corroborating that low-frequency stimulation induced LTD. However, the neuronal activity 24 hours after the training session exhibited higher discharge rates and became more stimulus specific than that in the pre-training session. These results imply that the spontaneous activity of dissociated neurons after LTD induces LTP and learning.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.141 No.5 （2021） 特集：神経工学

本誌掲載ページ: 654-660 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/141/5/141_654/_article/-char/ja/