Effect of Magnetic Nanoparticle Internalization on Cell Density in Skeletal Muscle Tissue

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2021/07/01

タイトル(英語): Effect of Magnetic Nanoparticle Internalization on Cell Density in Skeletal Muscle Tissue

著者名: Yuji Kirihara (Tokyo Institute of Technology), Hiromu Miyata (Tokyo Institute of Technology), Zugui Peng (Tokyo Institute of Technology), Kenta Shimba (The University of Tokyo), Yoshitaka Miyamoto (National Center for Child Health and Development), Kazuno

著者名(英語): Yuji Kirihara (Tokyo Institute of Technology), Hiromu Miyata (Tokyo Institute of Technology), Zugui Peng (Tokyo Institute of Technology), Kenta Shimba (The University of Tokyo), Yoshitaka Miyamoto (National Center for Child Health and Development), Kazuno

キーワード: skeletal muscle tissue，magnetic force，magnetite nanoparticle，internalization

要約(英語): The engineering of skeletal muscle tissue has gained considerable attention in recent years because of its clinical applications, which include muscle replacement and treatment of muscle-related disease. Magnetic nanoparticle internalization by skeletal muscle cells has been proposed as a means of improving cell density. In this study, by embedding magnetic nanoparticles in mouse C2C12 myoblast cells to engineer a muscle tissue sheet, we evaluated the cellular uptake of magnetic nanoparticles and their effects on cell proliferation and differentiation. Our results show a tendency for decreased muscle fiber thickness in C2C12 cells with internalized magnetite nanoparticles. However, no change was found in the number of cells or differentiation.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.141 No.7 （2021） 特集：電子材料関連技術の最近の進展

本誌掲載ページ: 795-801 p

原稿種別: 論文／英語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/141/7/141_795/_article/-char/ja/