microRNAと遺伝子の発現における統計的統合解析法

カテゴリ: 論文誌(論文単位)

グループ名: 【C】電子・情報・システム部門

発行日: 2024/04/01

タイトル(英語): A Statistical Integrative Analysis Method for MicroRNA and Gene Expression

著者名: 児玉　慶太（工学院大学大学院工学研究科），梅津　知宏（東京医科大学分子病理学分野），福岡　豊（工学院大学大学院工学研究科）

著者名(英語): Keita Kodama (Graduate School of Engineering, Kogakuin University), Tomohiro Umezu (Department Molecular Pathology, Tokyo Medical University), Yutaka Fukuoka (Graduate School of Engineering, Kogakuin University)

キーワード: microRNA，遺伝子（mRNA），遺伝子発現，統計的解析，シミュレーション　　microRNA，gene (mRNA)，gene expression，statistical analysis，simulation

要約(英語): MicroRNA (miRNA), a type of non-coding RNA, is known to suppress the expression of target genes and there is an increasing number of studies analyzing various miRNAs in cancer. In an integrated analysis of miRNA and gene expressions, it is often difficult to obtain a significant result with a small amount of data. In this study, we proposed a method that allows integrated analysis even with a small amount of miRNA and gene expression data, and examined its validity. The method is based on a group comparison between target genes having specific functions controlled by a specific miRNA and a background group of randomly selected genes. We conducted a simulation to verify the validity of the proposed method. The simulation results indicated that the method can detect significant differences in expression of target genes controlled by a miRNA showing significant expression change. We then applied the proposed method to real data derived from multiple myeloma cells. As a result, some functions were detected as significantly changed due to a significant change of miRNA.

本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.144 No.4 （2024） 特集Ⅰ：量子・情報・エレクトロニクスの医療/ヘルスケア応用　特集Ⅱ：電子回路関連技術

本誌掲載ページ: 290-295 p

原稿種別: 論文／日本語

電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/144/4/144_290/_article/-char/ja/